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|On Demand Webinar|| In Situ Monitoring of Chemical Reactions - Recent Advances in Organic Chemistry Part 3 |
In situ Fourier Transform Infrared (FTIR) provides real-time monitoring of chemical reactions and is suitable for a wide range of chemistries and applications. This presentation demonstrates how ReactIR™ supports the fundamental understanding of organic chemistry and enables chemical engineering research.
|On Demand Webinar|| Roller Compaction Process Optimization Using At-Line Particle Characterization |
One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.
|On Demand Webinar|| Simplify Process Characterization by Combining Thermal Data with In Situ IR Spectroscopy |
The capabilities and advantages of monitoring kinetics using online infrared (IR) techniques in combination with precisely controlled synthesis workstations or reaction calorimeters is presented using different reactions.
|On Demand Webinar|| Application of Quantitative Analysis to Predict Absolute Concentration Information in Real-time |
Relative concentration is sufficient for reaction progression information such as initiation, intermediate formation and endpoint. However, the ability to predict absolute concentration in real-time is sometimes desired or essential, especially during production monitoring, and for monitoring and controlling continuous processes. Part IV discusses the application of quantitative analysis using real-time in situ FTIR focusing on strategies that produce the best quantitative results for the desired outcome. Software tools for quantitative method evaluation will also be covered. This is Part IV of the webinar series - Introduction to Real-time In Situ FTIR for Rapid Reaction Progression Determination and Reaction Characterization.
|On Demand Webinar|| Innovative Approaches for the Synthesis and Purification of Peptide Libraries |
Peptide libraries are widely investigated and routinely screened for their drug-like properties. Synthesis using resins or solid supports is a favorite route for researchers performing peptide synthesis. However, synthesis and subsequent purification are major bottlenecks encountered during synthesis of peptide libraries. This webinar examines challenges related to the synthesis of peptide libraries and will discuss various applications including the synthesis of cyclic peptides employing a unique safety-catch linker, which enables the production of diverse libraries for biological screening.
|On Demand Webinar|| iC Quant™: What are Factors and How Are They Used in Quantitative and Discriminate Analysis? |
|On Demand Webinar|| Use of PAT and Laboratory Automation from the Pharmaceutical & Chemical Industries - New Developments |
Intergration of process analyzers and process automation together with the use of multivariate tools for design, data acquisition and analysis is critical and listed in Food and Drug Administration (FDA) guidance of Process Analytical Technology (PAT). Their use helps conduct information-rich experiments that respond to the need for increased process development throughput, downstream consistency and reliability.
|On Demand Webinar|| Introduction to Reaction Analysis Using Real-Time In Situ FTIR |
This webinar introduces the use of Fourier Transform Infrared Spectroscopy (FTIR) for reaction analysis and monitoring, and includes a comparison to other well known spectroscopic techniques. The method of measurement and probe and sensor options available will be discussed as well as best practices on how to collect high quality data that will facilitate easy interpretation.
|On Demand Webinar|| The Importance of Mixing: How to Compare Lab Scale Mixing with Full Scale Process Vessel Performance |
Process objectives are critical for successful manufacturing of a product. If the mixing scale-up fails the required yield, quality, or physical properties of the product and the costs of manufacturing may be significantly increased . Failure to provide the necessary mixing may result in severe manufacturing problems on scale-up, ranging from costly corrections in the plant to complete failure of a process. The costs associated with these problems are far greater than the cost of adequately evaluating and solving the mixing issues during process development. Conversely, the economic potential of improved mixing performance is substantial. Therefore, at the heart of any scale-up chemical process, there has to be a fundamental understanding of how the mixing processes in a lab reactor compares to the mixing performance of a full scale process vessel which is targeted to receive the lab developed process.
|On Demand Webinar|| 20 Years of Reaction Calorimetry at Johnson and Johnson |
Learn how Johnson and Johnson avoids chemical reaction hazards using reaction calorimetry.
|On Demand Webinar|| In Situ Flow Technology to Continuous Processing - Part I |
The ReactIR™ flow cell is presented as a convenient inline analytical tool for continuous flow chemistry processing. The flow cell, operated with ATR technology, is attached inline using standard Omnifit® connections. With the established iC IR 4.0 software the consumption of reagents and formation of products can be monitored in real-time, allowing for rapid optimization. Unstable reactive intermediates can also be observed in situ, giving mechanistic insight to complex transformations.
|On Demand Webinar|| Role of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering |
Process Analytical Technology (PAT) case studies are presented on how the principles of Green Chemistry and Green Engineering have been leveraged in chemical reactions and crystallization design.
|On Demand Webinar|| Bottling & Filling of Substances for Commercial Use and Internal Reference |
In the current global climate, all companies and industries are looking for ways to increase their productivity and reduce their costs. For manufacturers and distributors of fine chemicals, reference materials and standards and particularly those who are concerned with bottling, filling and repackaging of small quantities of chemicals (e.g. 1mg -250mg), there is an automated powder dosing solution that will revolutionise your processes.
|On Demand Webinar|| Conversion Prediction of an Enzymatic Esterification |
This online seminar focuses on the implementation of FTIR-based online analytics in the production of fatty acid esters. A new process using Novozym 435 as a catalyst in a highly viscous solvent free environment was developed and tested at pilot scale. The optimization of operation parameters and process control analytics using FTIR for this process will be discussed.
|On Demand Webinar|| Chemical Synthesis and Optimization Supported by Design of Experiments (DoE) - Lonza Peptide |
Learn how Design of Experiments (DoE) is applied to chemical synthesis at Lonza Peptide.
|On Demand Webinar|| Safe Scale-up of Chemical Processes at Chilworth |
This presentation discusses how to ensure the safety of a process, when they should be performed, and how the outcomes of the tasks should be integrated to maximize the benefit. The safety of a process is not purely the domain of chemical engineers. Chemists dictate the intrinsic hazards of the process.
|On Demand Webinar|| Reducing Out-of-Specification Results in QA/QC |
Weighing out powders to prepare samples and standards for analytical methods such as HPLC can be a time-consuming task with high error risk. With the advent of faster analytical methods, such as UHPLC, and rapid advances in software developments providing faster data processing, attention is once again focussing on sample preparation as the bottleneck in the process.
|On Demand Webinar|| Streamline your powder dosing |
There are many stages in the drug discovery process where powder dosing is required, in varying target amounts and batch sizes, and into a wide range of different target containers. As new drugs become more effective and more potent, there are also greater risks for the people who are exposed to these compounds during development and formulation. Mettler Toledo’s Quantos automated powder dosing technology has been successfully applied to capsule filling, commercial bottling/filling and QA/QC applications. See how Quantos can improve these processes in terms of quality, productivity and user safety, ultimately saving time and money.
|On Demand Webinar|| Improving the Understanding and Control of Polymer Synthesis |
This presentation discusses emerging polymer research and how the value of real-time in situ FTIR (Fourier Transform Infrared) spectroscopy contributed to the understanding of the polymerizations.
|On Demand Webinar|| In Situ Reaction Monitoring - Recent Advances in Organic Chemistry Part 5 |
By using in situ FTIR creatively, researchers uncovered reaction mechanisms, further understood reaction kinetics and identified reaction intermediates. ReactIR™ provided key information to not only analyze and understand the chemistry but also on reaction rates under pressure - without upsetting the reaction.
|On Demand Webinar|| Carbon-carbon Coupling Reactions Using Silica Supported Catalysts for Reaction Screening and Library Generation |
|On Demand Webinar|| Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining the Study of Complex Organic Reactions |
During Part II of this free webinar series, Donna Blackmond continued to discuss how the Reaction Progress Kinetic Analysis (RPKA) methodology simplifies kinetic studies of organic reactions. Part II focuses on process robustness.
|On Demand Webinar|| Optimization and Scale-Up of Anti-Solvent Addition Crystallizations From Lab to Pilot Plant |
This two part crystallization webinar series is based on an award winning paper presented at the 16th International Process Development Conference. The webinar series focuses on a semi-quantitative method for the optimization and scale-up of hydrodynamically limited anti-solvent crystallization process. This protocol combines in situ Process Analytical Technologies (PAT) with Computational Fluid Dynamics (CFD) to facilitate the production of a knowledge based scale-up strategy for this mixing limited crystallization process.
|On Demand Webinar|| Building Green Pharmaceutical Manufacturing on a Foundation of PAT and QbD |
|On Demand Webinar|| Quick and easy capsule filling for pre-clinical and clinical trials |
The first step in preparation of pre-clinical and clinical trials is manually weighing in highly potent, hazardous substances precisely with a spatula. This webinar looks at the real practicalities of capsule filling, with a focus on the requirements for use in pre-clinical and clinical phase 0 and 1 trials, and introduces a quick, easy and precise automated solution.