Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a PAT Tool - METTLER TOLEDO
 

Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a PAT Tool

The use of real-time in situ mid-infared (mid-IR) analytics as a Process Analytical Technology (PAT) tool early in process development has become widespread particularly in the pharmaceutical industry in order to run information rich experiments which results in shorter project timelines. Not only does this result in meeting Quality by Design (QbD) objectives, but it also results in the ability to move processes to the manufacturing environment faster.
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Reducing Time to Manufacturing Using Real-time In Situ FTIR Analytics as a PAT Tool

Case studies will be used to illustrate how real-time mid-infrared (mid-IR) analytics provide critical information that results in shorter process development timelines, including:

  • Intermediate detection during an indazole alkylation and scale-up - Pfizer
  • Hazardous gas detection during a tetrazole synthesis - Merck
  • Monitoring a Grignard reaction at the multikilogram scale - Bristol-Myers Squibb
  • Scale-up involving a sensitive enolate - Johnson and Johnson (J&J)
Your online presenter, Will Kowalchyk, has extensive experience in fourier transform infrared spectroscopy (FTIR) reaction analysis.

Related topics: Fourier transform infrared spectroscopy, FTIR, FT-IR, chemical development, PAT, Process Analytical Technology, indazole alkylation, tetrazole synthesis, Grignard reaction, sensitive enolate, in situ FTIR, manufacturing process, process development, Quality by Design, QbD, in situ reaction spectroscopy, iC IR, ReactIR, reaction analysis software, organic process research, Will Kowalchyk

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