Process Safety - METTLER TOLEDO
 

Process Safety

Process Safety

Detect Thermal Hazards Early and Design Safety Into The Chemical Process

Developing process safety designs enables chemists and engineers to keep the reaction under control as well as assessing process dynamics which is important for process development. In the chemical and pharmaceutical industries, most processes are carried out in batch or semi-batch mode. The hazard potential and risk of chemical processes are related to reactivity and toxicity of chemicals involved and the process design itself.

While the toxicity of the reagents cannot be influenced, the appropriate design of a process is essential to keep the reactor under control at any given time. As there is no steady-state in batch and semi-batch operations, process dynamics also becomes an important factor and needs to be assessed carefully. Consequently, striving for process safety is the goal of process development.

Crucial for the development of a safe manufacturing process is the availability of information describing the process, the toxicity and stability of the individual raw materials, intermediates and final products.

METTLER TOLEDO provides a complete toolbox to support process safety studies and characterization of the thermal behavior of batch and semi-batch reactions:

  • Thermal Analysis for characterization of decomposition profiles - identifying potential of explosions and runaway reactions
  • RC1 Process Safety Workstation for monitoring heat of reaction under normal operating conditions with accurately controlled temperature, pressure, dosing rates. RTCal provides real time heat of reaction measurement - for isothermal and non-isothermal processes -without the need for calibration
  • Reaction monitoring (in situ FTIR with ReactIR) for a full picture of reaction mechanisms and kinetics - including detection of intermediates and side reactions
  • iC Safety Software to automate the calculation of of standard thermal safety values - heat of reaction, thermal conversion, thermal accumulation, adiabatic temperature rise, Maximum Temperature of Synthetic Reaction (MTSR).