TGA-Sorption System

Measurements with controlled humidity

The TGA-Sorption System is designed to analyze materials under defined conditions of temperature and relative humidity (RH).

Unique flexibility – a highly sensitive thermobalanace combined with full sorption analysis capability
Defined environment – the effect of moisture and temperature on material properties can be easily investigated
Pre-conditioning versatility – methods allow the use of elevated preconditioning temperatures (up to 150 °C)

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The design concept combines the performance and versatility of the large furnace TGA/DSC 1 or TGA/SDTA85xe thermobalance with a unique interface approach that allows a humidity generator to be connected via a transfer line within a few minutes.

Measurements at controlled relative humidity provide information that is crucial for understanding the effects that moisture content can have on the properties of a wide range of materials:

Processing – spray-dried powder that becomes moist can potentially block production equipment
Product shelf life – can be shortened by moisture uptake due to inadequate packaging
Structural properties – moisture content can reduce bioavailability and influence the therapeutic effect

Dynamic sorption curve

The TGA curve shows the uptake and release of moisture by a sample of amiloride hydrochloride dihydrate as a function of relative humidity (RH). The stages of the analysis include:

Temperature program with a preconditioning segment (dehydration) at 125 °C (dotted line)
Increase of RH in steps of 10% with equilibration (red curve)
Resulting weight changes for each 10% change in RH (black curve)

At a RH of about 50%, the substance has regained its original water of crystallization. Further increase of RH results in the uptake of free surface water. This is liberated when the RH is reduced.

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